SEO PTT的問題，透過圖書和論文來找解法和答案更準確安心。 我們找到下列懶人包和總整理

SEO PTT進入發燒排行的影片

功能性胜肽偶聯金奈米棒在靶向光熱治療之應用

為了解決SEO PTT的問題，作者Siva sankari Sivasoorian 這樣論述：

Antibiotic resistance and impaired wound healing are the main challenges associated with wound care caused by multidrug-resistant (MDR) pathogens. To combat the bacterial wound infection and accelerate wound closure, we synthesized an antimicrobial peptide-conjugated (LL-37) gold nanorod and a neur

opeptide-conjugated gold nanorod that can bind with bacteria based on electrostatic interaction. The GNR-peptide conjugates showed good biocompatibility, sufficient stability, enhanced targeting, the potential photothermal killing of bacteria, and possible acceleration of wound healing. The photo-bi

omodulation properties of NIR improved the wound closure rates through enhanced cell migration.The multifunctional LL37-conjugated GNRs significantly enhanced photothermal therapeutic outcomes based on bacterial targeting with promising wound healing properties (Chapter 1). We studied the neuropepti

de (ANGIOPEP-2) conjugated gold nanorod’s efficiency to enhance the cellular uptake of the metal nanoparticle in order to achieve effective photothermal therapy in gliomas. We evaluated five glioma cells for LRP1 expression as ANGI-2 targets specificity for this peptide. Among the five glioma cells

(C6, F98, AST1,9L, and U87), C6 has the highest LRP1 expression, hence chosen as the cell model for further studies. We evaluated the cell viability with NIH3T3 fibroblast cells, and the conjugate showed no significant cytotoxicity. The in vitro therapeutic effect of the conjugate with sham or laser

exposure showed 40% cell death assessed by MTT assay. We evaluated the ROS production with two time periods of exposure, 12 min and 24 min. The conjugate with laser exposure showed higher ROS production at 24 min, provided that time increment of laser exposure will help improve the oxidative stress

. To evaluate the cell death pattern, we used caspase and RIPK 1 inhibitors to study their effect on the PTT induced by the conjuga. The cell death pattern was found to be caspase-dependent apoptosis. We further evaluated the expression of tumor suppressor p53, apoptosis effectors caspase-3/7, and B

cl-2 protein using western blotting. Western blotting studies indicated the conjugate follows two different pathways depending on the sham or laser exposure. With sham exposure, theconjugate follows p53/Bcl-2 mediated autophagy inhibition, causing low or no cytotoxicity to glioma cells. With laser e

xposure followed by increased oxidative stress, the conjugate followed the p53/miR34a/Bcl-2 mediated caspase pathway of apoptosis and enhanced cell death.