Interfere with sb的問題,透過圖書和論文來找解法和答案更準確安心。 我們找到下列懶人包和總整理

Interfere with sb的問題,我們搜遍了碩博士論文和台灣出版的書籍,推薦顧南華寫的 英語口語,自己學:英語口語常用短語和表達方式 和張立麗(主編)的 英語四、六級詞組辨析手冊(高級)都 可以從中找到所需的評價。

另外網站The Relationship between Mental Health, Mental Illness也說明:These physical changes interfere with cardiovascular function and significantly ... S.B. Patten, “Long-Term Medical Conditions and Major Depression in the ...

這兩本書分別來自化學工業 和化學工業所出版 。

國立陽明交通大學 臨床醫學研究所 林幸榮、黃柏勳所指導 陳其宇的 血管再塑形在心血管疾病之角色-從飲食到基因調控之研究 (2021),提出Interfere with sb關鍵因素是什麼,來自於動脈粥狀硬化、血管內膜新生、血管再塑型、血管平滑肌細胞、四個半LIM的結構蛋白2、氧化三甲胺、3、3-二甲基-1-丁醇、內質網壓力。

而第二篇論文臺北醫學大學 國際醫學研究博士學位學程 葉篤學、高祖仁所指導 Ivan Limanjaya的 鈣離子信號傳導於細胞連結動態所扮演的角色 (2021),提出因為有 L-selectin、blood-testis barrier、spermatogenesis、calcium、tight junctions、ASC-17D、Rho GTPase的重點而找出了 Interfere with sb的解答。

最後網站interfere with sb中文(繁體)翻譯:劍橋詞典則補充:interfere with sb 翻譯:猥褻(幼童)。了解更多。

接下來讓我們看這些論文和書籍都說些什麼吧:

除了Interfere with sb,大家也想知道這些:

英語口語,自己學:英語口語常用短語和表達方式

為了解決Interfere with sb的問題,作者顧南華 這樣論述:

通過對本套書的第二分冊「英語口語高頻動詞」的學習,讀者可以深刻地領會到:學習英語口語高頻動詞,擴大讀者的英語動詞的詞匯量,是說好流利英語口語必不可少的環節。但是,在英語口語中,還有大量常用的短語和表達方式,這些都是英語中的習慣用法。讀者要說一口流利地道的英語,必須掌握這些常用的短語和表達方式。本分冊通過對國內外近百種英語口語書和托福口語試題的分析和總結,精選出英語口語對話中常出現的短語和表達方式。讀者掌握和運用這些短語和表達方式,就能更有效地提高英語口語水平。 Lesson One a cup of tea, ’’s cup of tea, a (big, good) de

al, It’’s a deal , It (this) is not a big deal, a piece of cake, a small world Lesson Two account for, adapt to, addict to, after all Lesson Three apart from ( =except for) , appeal to, apply for, as a matter of fact Lesson Four as a result, as far as I know (I’’m concerned), as usual, attach import

ance to Lesson Five aware of, hack up, based on, be certain (for certain) Lesson Six be my guest, be sure (to do), bear (keep) in mind, beat around (about) bush Lesson Seven believe it or not, blame for (blame no one but), break down, break up with Lesson Eight huy one’’s story, by all(no)means, by

the way, can down Lesson Nine care about, care for, would you care for...?, carry out, cautious about Lesson Ten check out, cheer up, clean out (up), clear up Lesson Eleven come across, come down to, come true, come up with Lesson Twelve comment on, communicate with, compare with (to) ,concentrate o

n Lesson Thirteen concerned about, contribute to, make contribution to, couldn’’t help, count on Lesson Fourteen curious about, cut hack on, cut down (on), deal with (cope with) Lesson Fifteen depend on, devote to, do one a favour, drop off Lesson Sixteen due to, end up (with), cnquirc (inquire 美國拼法

) about, cquip with Lessen Seventeen fall down, familiar with, far form, feed (常用 be fed) up with Lesson Eighteen feel free, feel like, figure out, fill out (in) Lesson Ninetecn focus on, for...sake, for sure (that’’s for sure), frankly (generally) speaking Lesson Twenty from the point of view, from

my point of view, get along (with), get down to, get down to business, get (run) into (in) trouble Lesson Twenty—One get in (keep) contact with, make a contact with, get (be, keep) in touch with, lose touch with, get (be, become) involved with, get (let, set) one down Lesson Twenty—Two get on nerve

s, gct on sb’’s nerves, get rid of, give (lend, need) a hand, give one a lift (ride) Lesson Twenty—Three give up, go Dutch, grow up, hang on, hang something on Lesson Twenty—Four hang out, have a sweet tooth, have (make) an appointment with, have (feel) confidence in, lack (lose) confidence in Lesso

m Twenty—Five have (produce) an effect on, have (bring, cause) an impact cn, have something (nothing, anything) to do, hold up Lesson Twenty—Six hook up (to) , hurry up, I can’’t agrce more, in a good (had) mood, in the (no) mood for Lesson Twenty—Seven in a hurry (in a rush), in addition, in additi

on to, in advance, in charge of Lesson Twenty—Eight in detail, in good (had, poor, terrible) shape (condition,order) , in (out of) fashion, in one’’s opinion Lesson Twenty—Nine in particular, something (nothing, anything) in particular, in stock (out of stock) , in terms of, interfere with (in) Less

on Thirty in that case, it (that) doesn’’t matter, it’’s (that’’s) a pity, it’’s a (my) pleasure Lesson Thirty—One it’’s (that’’s) a shame, it’’s hard to, (do) , it’’s hard to say, it’’s my treat, it’’s one’’s fault Lesson Thirty—Two it’’s (that’’s) true, that’’s can’’t be true, it’’s up to, one, it

’’s usual (general) practice, jump (come) to (reach) a conclusion Lesson Thirty—Three keen on, keep an eye on, have an eye on, keep track of,keep up with Lesson Thirty—Four lay off, lead to, leave (make) a mess (in a mess), leave (give, take) a message (note) Lesson Tirty—Five let alone, let one kno

w, log in/on ( get on, go to, have access to) internet, log out of, look for Lesson Thirty—Six look fonvard to.lose heart (lose courage) , lose (take off, keep down , reduce) weight, gain (put on) weight, major in Lesson Thirty—Seven make a complaint, make (take) an effort to, put effort into, make

an impresssion, make a reservation (booking) Lesson Thirty—Eight make sense, make sure, make up (for), mess up Lesson Thirty—Nine no problem, no wonder, now that, object to Lesson Forty on a diet, on business, on a trip, travel on business, on earth, what on earth, on one’’s own Lesson Forty—One on

one’’s own account, on any (no) account, on purpose, on the contrary (quite the contrary) , out of date, out of style Lesson Forty—Two pay attention to, pay for, pay off, pick up Lesson Forty—Three pile up, play a role for (in), Play less a role in, pop up (in), popular with Lesson Forty—Four preven

t from, provide with, put (place) emphasis on, put down Lesson Forty—Five put off, put up, put up with, qualify for (be qualified for), queue up Lesson Forty—Six regard as, refer to, related to, rely on Lesson Forty—Seven rest assured (rest easy), right away, run (to be) out of, run out of gas, sati

sfy with (be satisfied with) Lesson Forty—Eight search for, set off, set up, settle down Lesson Forty—Nine show off, show up, sign up, slip one’’s mind Lesson Fifty so far, something wrong with, sort out, speaking of, speaking well (highly, ill) of Lesson Fifty—One split up (with), stand for, stay u

p late, start with, to start with Lesson Fifty—Two stick to, suffer from, switch to, take it easy

血管再塑形在心血管疾病之角色-從飲食到基因調控之研究

為了解決Interfere with sb的問題,作者陳其宇 這樣論述:

血管重塑是一個複雜的病生理過程,在心血管疾病的臨床表現中有著重要作用。重塑的一個重要概念是保持恆定血流。實驗和臨床觀察顯示,血管重塑與內膜中層增厚(intima-media thickening, IMT)和動脈粥狀硬化斑塊形成有關。受動脈粥狀硬化影響,血管壁上維持穩定環境的生理需求增加。為應對不斷增長的斑塊,血管壁會發生重塑以補償血流的變化。血管平滑肌細胞(vascular smooth muscle cells, VSMC)在動脈粥狀硬化發展過程中調節血管壁重塑具有重要作用。我們希望通過這一系列研究,了解血管平滑肌細胞在心血管疾病中的作用。在研究的第一部分,我們研究了四個半LIM的結構蛋

白2 (four and a half LIM domain protein 2, FHL2)在血管重塑中的機制。FHL2是FHL基因家族的成員,它與富含膽固醇的飲食促進動脈粥狀硬化有關。然而,FHL2 蛋白對受到血流動力學改變之血管重塑的影響仍不清楚。在這裡,我們研究FHL2在受限血流誘導的動脈粥狀硬化模型中的作用。為了誘發體內血管內膜增生,我們對 FHL2+/+和FHL2-/-小鼠執行左頸動脈(left carotid artery, LCA) 部分結紮。在 FHL2-/-小鼠中p-ERK和p-AKT的表現下降。FHL2與AKT結合作用調節AKT磷酸化並導致Rac1-GTP失去活性。在人類

主動脈平滑肌細胞中降低FHL2表現能減少血小板衍生生長因子(platelet-derived growth factor, PDGF)誘導的ERK和AKT磷酸化。此外,FHL2表現量降低減少細胞骨架結構的變化並導致細胞週期停滯。我們認為FHL2 對於調節動脈平滑肌細胞功能至關重要,FHL2通過有絲分裂原活化蛋白(Mitogen-activated protein kinase, MAPK) 和 PI3K-AKT 機轉調節細胞增生和遷移,導致動脈壁增厚造成血管內膜增生。在研究的第二部分,我們探討攝入過多的氧化三甲胺(trimethylamine‐N‐oxide, TMAO)是否會造成血管發炎而促

進血管重塑。近來研究顯示,由於TMAO刺激血管發炎,因此被認定為是造成動脈粥狀硬化的危險因素。然而,TMAO對血管損傷後內膜增生的影響仍不清楚。我們在小鼠模型上,藉由餵食高含量的TMAO飲食,以更深入地了解TMAO在血管損傷中的機制。本研究是在小鼠模型上利用左頸動脈部分結紮以模擬急性血流改變。3,3-二甲基-1-丁醇(3,3-Dimethyl-1-butanol, DMB) 是膽鹼的一種結構類似物,用於競爭性結合以降低體內TMAO的濃度。將野生型(wild-type, WT)小鼠分為四組[常規飲食、高 含量TMAO飲食、高含量膽鹼飲食和高含量膽鹼飲食+ DMB] 以研究TMAO 升高及DMB抑

制效果對血管病變的影響。與對照組相比,餵食高含量TMAO 和高含量膽鹼飲食的小鼠顯著增加了血管內膜增生和晚期斑塊,而DMB治療減少了血管內膜和中層增生。此外,高含量TMAO和高含量膽鹼飲食造成結紮誘導的動脈彈性蛋白碎裂、增加巨噬細胞浸潤、細胞發炎因子分泌,並活化核因子活化B細胞κ輕鏈增強子(nuclear factor kappa-light-chain-enhancer of activated B cells, NF-κB)和NLRP3發炎體。給予TMAO抑制劑DMB治療可以顯著減少了血管損傷、發炎體、內質網壓力和活性氧的表現。我們的研究結果顯示,TMAO升高會促進血管病變,而給予DMB可

以減緩血管重塑,在此說明了TMAO可以做為治療標的,來減緩動脈粥狀硬化與避免血管內膜再狹窄的理論基礎。調控血管重塑的過程涵蓋了內在的基因表達到外在的攝取物的影響,基因表達的調控協調重要的細胞過程,包括細胞增生、分化和發炎。血管滑肌細胞中的轉錄因子表達和細胞週期調節受FHL2的調節,且會隨著血管損傷而變化。 FHL2是否可以作為疾病生物標誌物將取決於更多不同疾病患者上的發現。微生物群的代謝物與疾病的危險因素之間存在相關性,除了腸道微生物群外,宿主遺傳、共同代謝和飲食也會對產生TMA和TMAO有影響。如果可以研究微生物群在調節TMAO濃度的具體作用及其飲食調節機制,將能夠成為改善患者預後的新治療目

標。

英語四、六級詞組辨析手冊(高級)

為了解決Interfere with sb的問題,作者張立麗(主編) 這樣論述:

本書匯集了英語詞組173組。包括動詞詞組、介詞詞組、名詞詞組、形容詞詞組、副詞詞組和慣用詞語等。介紹了詞組意義、搭配、辨析、應用,尤其是通過大量例句,闡明詞組間的異同和應用。是適用於英語學習者,備考、提高英語水平的參考書。 1 a bag of; a sack of001 2 a bale of; a box of; a bundle of; a pack of; a package of; a packet of001 3 a cup of; a glass of; a mug of003 4 above all; first and foremost; first of

all; in the first place 004 5 absorb in; apply(bend; give; put; set; turn)one』s mind to; apply oneself to; attend to; bury(oneself)in; devote(oneself)to; settle down(to); soak(oneself)in; steep(oneself)in006 6 according as; according to; in accordance with009 7 account for; go into; set out010 8 al

ive to; awake to; aware of; beware of 011 9 all at once; all of a sudden; in a flash013 10 all in; tire out; use up; wear out014 11 all in all; as a whole; at large; by and large; in all; in a word; in general; in one word; in the large; in sum; on the whole; to sum up; upon the whole015 12 all mann

er of; all sorts(kinds)of; of all sorts(kinds); this,that and the other; this and that018 13 all over; far and near; far and wide; here and there; here there and everywhere; on all sides; on every side; right and left; left and right020 14 allow for; get around to; get round to; see about; take acco

unt(consideration)of; take into account(consideration); think about; think of; think out; think again; think over; think twice; think through; use one』s head; take no account of022 15 and all; and that; and all that; and so forth; and so on; and the like; and what not; what have you; and what—not028

16 and no mistake; beyond doubt; beyond question; no doubt,out of question; without doubt; without question030 17 and way; at all events; at any cost; at any price; at any rate; by all means; by any means; by every means; in any case; in any event032 18 appear in print; in print; bring out; come ou

t; put out034 19 apply to; do with; have a connection with; in connection with; refer to; relate to; be related to; relative to; tie in with; tie up with036 20 approach to; close on; close to; close upon; come near to; come close to038 21 argue into; persuade into; reason into; talk into039 22 arise

from; arise out of; come from; come of; flow from; grow from; grow out of; result from040 23 as a matter of fact; as good as; as it is; as it was; in actual fact; in effect; in fact; in point of fact; in reality; in practice; in truth042 24 as far as; as for; as regards; as to; in regard to; in one

』s regard; in this regard; in that regard; so far as; with regard to045 25 as if; as it was; as it were; as it is; as though; look like047 26 as long as; in case; in case of; in the case of; in the event of; in the event that; on condition of; on condition that; on the understanding that; provided t

hat; providing that; so long as049 27 as soon as; barely...when; hardly...before; hardly...when; no sooner...than; scarce...before; scarcely...before; scarcely...when; so soon as; the instant; the minute; the moment053 28 as yet; so far; to date; up to date; up to now; up to the present055 29 ascrib

e to; attribute to; charge off to; charge to; put down to056 30 at large; at length; in detail057 31 at random; at will058 321at rest; breathe one』s last; die off; drop dead; go home; draw one』s last breath; go to one』s rest; go west; in the dust; kick the bucket; pass away; go to one』s account; go

to one』s last home; breathe one』s last breath058 33 at sixes and sevens; in a mess062 34 at table; dine in; dine on; dine out; dine out on; at the table; eat away; eat off; eat up; wolf down; dine off; finish off; finish up062 35 attend on; attend upon; run after; run round; wait on; wait upon065 36

attend to; clear up; cope with; deal with; reckon with066 37 auction off; clear off; close out; go for a song; go for an old song; for a song; knock down; knock sth.down to sb.for; sell for a song; sell off; sell out; sell up068 38 avail(oneself)of; cash in on; make use of; trade on; trade upon071

39 back down; back off; fling in; fling up; give up; throw in; throw up073 40 back out; back out from; back out of; break one』s word; break one』s promise; go back from; go back of; go back on; go back upon074 41 back up; block up; bung up; stop up076 42 back up; in support of; stand behind; stand by

; stand for; stand up for077 43 bang up; crack up; finish off; smash up079 44 bang up; get sb.into trouble; knock up; prang up080 45 bank on; calculate on; calculate upon; count on; count upon; depend on; depend upon; dependant on; dependant upon; lean on; lean upon; look to; reckon on; reckon upon;

rely on; rely upon; rest on; rest upon081 46 barge in; barge in on; barge into; break in; chip in; cut in; edge in; get in; get in a word; put in; cut in on; cut into084 47 base on; base upon; build on; build upon; found on; found upon; ground on; ground upon; repose on087 48 bear a grudge; carry a

grudge; have a grudge; hold a grudge; have it in for089 49 bear with; do with; hold with; put up with; stand for; take it090 50 beat down; bring down; come down; cut down; knock down; knock off091 51 because of; as a result of; by right of; by virtue of; due to; in that; in view of; in virtue of; o

n account of; owing to; thanks to094 52 behind closed doors; in private; in secrecy; in secret; in the dark; under the table098 53 bet on; gamble on; put on; stake on; stake upon; wager on100 54 betroth to; engage to; promise to102 55 bitch up; foul up; make a hash of; make hay of; make a mess of; m

ake a muddle of; mess up103 56 blaze up; burn up; catch alight; catch fire; catch on fire; flame forth; flame out; flame up; on fire; set fire to sth.; set sth.on fire105 57 bone up on; mug up; swot up; bone up; mug up on; swot at107 58 born of; be from; come from; come of; hail from; spring from; b

e born of; be sprung from108 59 bow before; bow down to; bend the knee to; bow the knee to; bow to; yield to110 60 box in; box in up; hem about; hem around; hem in111 61 break down; call a halt; come to a halt; come to a standstill;come to a stop; cut out; give over; leave off112 62 break down; cut

out; give out; go wrong114 63 break one』s neck; do one』s best; do one』s endeavour; do one』s utmost; go flat out; exert oneself; go all out; try one』s best; make one』s endeavour; make every endeavour115 64 brighten up; cheer up; chirk up; perk up; spunk up; bear up; brace up; buck up118 65 bring abou

t; bring on; lead to; result in; result from119 66 bring back; bring to mind; call to mind; put in mind; recall to mind; think back121 67 bring down; come down; hand down; hand on; pass down; pass on123 68 bring forth; bring forward; bring up; put forth; put forward;put up124 69 bring forth; bring i

nto the world; come into the world; deliver of; give birth to126 70 bring forward; in advance; in advance of; put ahead; set ahead; set forward128 71 bring out; put out; turn out130 72 bring to an end; come to a close; draw to a close131 73 bring to ruin; burst up; come to ruin; go bankrupt; go brok

e; be broke; go bust132 74 bring up; bring back; cast up; come up; spit up; throw up133 75 buck up; come along; come on; hurry up; make haste; make speed135 76 build up; lay aside; lay away; lay by; lay in; lay up; place aside; put apart; put aside; put away; put by; save up; set aside; set by136 77

bundle sb.off; pack sb off; send sb.off; ship sb.off; send away138 78 butter up; lick sb』s boots; polish the apple; lick sb』s feet; lick sb』s shoes140 79 buy off; get al; get to; take care of141 80 by dint of; by means of; by right of; by virtue of; in virtue of142 81 by rotation; by turns; in rota

tion; in turn,take turns; take it in turn(s); take one』s turn144 82 call at; call by; call in; call into; call on; call upon; drop by; drop in; drop on; drop over; have a visit to; look up; make a visit to; pay a visit to; wait on; wait upon; drop into; drop round146 83 call off; wash out; wipe out;

write off149 84 call sb.names; call sb』s name; call sb.by name; blast away; blast off; let out; swear about; swear at151 85 call up; phone up; place a call; put a call; give a call; make a call; ring to; ring up; telephone in152 86 calm down; cool down; cool off; die away; die down154 87 carry on;

get on; go on; keep on; keep doing155 88 carry over; hold back; keep back; put back; set back158 89 cast an eye at; cast an eye over; glance over; glance through; look through; run through; skim over; skim through; skip through; glance one』s eye over; glance one』s eye through159 90 cast aside; cast

away; cast out; fling away; fling out; throw away; throw out; toss away; toss out162 91 cast off; draw off; get off; pull off; put off; slip off; take off;throw off163 92 catch hold of; clap hold of; clutch at; get hold of; grab at; lay hold of; seize hold of; snatch at; take hold of166 93 catch on;

cotton on; figure out; get al; make out; pick out; take in; work out169 94 catch some z』s; catch one』s breath; crash out; dead to the world; forty winks; get a break; go to sleep; have a break; have a rest; hit the hay; hit the pad; hit the sack; hit the slats; take a break; turn in172 95 catch up;

catch up on; catch up to; catch up with; come up with; get up with; keep up with176 96 chalk out; lay down; map out; set down; work out178 97 chalk up; mark down; make note(s)of; note down; put down; set down; take down; take note(s)of; write down180 98 change up; gear up; speed up; step on the gas

183 99 cheat out of; do out of; swindle out of; trick out of184 100 check out; check over; check through; check up; check up on; go over; go through; look over; look through186 101 chip in; come down with; come through; give financial aid; aid financially; kick in; offer assistance189 102 chuck down

one』s tools; be on(a)strike; come on(a)strike; come out on(a)strike; down tools; fling down one』s tools; go on(a)strike; go out on(a)strike; be on(a)strike; throw down one』s tools191 103 chuck out; throw out; toss out; turn away; turn down192 104 chuck up; give up; resign from; step down; throw up1

94 105 chum in(with); chum up(with); be friends with; keep company with; make friends with195 106 clean up; coin money; earn an honest penny; earn good money; make a fortune; make a pile; make money; mint money; net a profit; turn an honest penny197 107 close down; close one』s doors; close out; clos

e up; close up shop; shut down; shut up; shut up shop200 108 collaborate with; cooperate with; play ball(with); team up(with); work together202 109 combine with; link up204 110 come across; come on; come upon; drop across; fall across; happen on; happen upon; meet up; meet up with; meet with; run ac

ross205 111 come away; get along; get away; get out; go along; go away; move away; move off; walk away; walk off209 112 come out; show one』s face; show up; turn up212 113 come the old soldier over; cross up; play false; try on; play the old soldier; come over,come around213 114 compensate for; make

amends for; make up; make up for215 115 cook up; fake up; make up; think up216 116 cope with; get around; get round; get over; tide over217 117 count off; cream off; drop on; fasten on; pick on; pick upon;pick out; pick over219 118 crack up; cry up; extol to the skies; laud to the skies; give someon

e a pat on the back; pat someone on the back; praise to the skies; slap someone on the back221 119 cross off; cross out; cut off; cut out; score off; score out; strike off; strike out; strike through223 120 cry down; do down; run down; tell tales out of school225 121 cut across; cut corners; cut thr

ough227 122 date(back)to; date(back)from; go back into; go back to;run back to; trace back to228 123 decide on; decide upon; determine on; determine upon; make up one』s mind229 124 deliver over; deliver up; give in; give over; hand in; hand over; turn in; turn over230 125 demur at; disagree about; d

isagree on; disagree over; disagree to; disagree with; stand out against; stick out against233 126 depend on; depend upon; hang on; hang upon; hinge on; hinge upon; ride on; ride upon; turn on; turn upon235 127 die by; die from; die in; die of; die off; die out; die with236 128 die down; die out; go

out; snuff out239 129 dine off; eat off; live by; live off; live on; sponge on; sponge upon240 130 dine off; feed off; feed on; feed upon; live off; live on242 131 dismiss from; fire out; kick out; let go; fire from244 132 do into; put into; render into; translate into; turn into245 133 do sb.to de

ath; finish off; kill off247 134 dot sb.』s i』s; dot sb.』s i』s and cross sb.』s t』s; find fault with; pick a hole in; pick holes in sb』s coat; pick flaws in sb』s coat; pick at248 135 draw on; dress up; get into; go into; have on; pull on; put on; throw on; turn out250 136 drive at; get al253 137 drive

crazy; drive mad; drive sb.insane; drive sb.out of one』s mind(wits); drive sb.up the wall; send sb.up the wall; sick of; sicken of; tire of; sick to death of254 138 drop a brick; put one』s foot in it; put one』s foot into it; put one』s foot in(into)one』s mouth256 139 drop off; get off; get out of; l

et off; put down; put off; set down257 140 eat up; make away with; make off with; run away with; run out; run out of; run through ; use up259 141 edge on; egg on; goad on; put up to; set on; urge on262 142 fall foul of; fall afoul of; have a quarrel(with); have words; exchange words with; have words

with; pick a quarrel with; quarrel with; run afoul of; run foul of264 143 fill in; fill out; fill up266 144 follow the fashion; keep up with the Joneses; keep up with the times; try to be in the trend267 145 fool around with; meddle with; mess about with269 146 foot the bill; pay back; pay down; pa

y for; pay up; put down; tip up270 147 for ever; for ever and a day; for good; for good and all; for keeps271 148 for sb』s sake; for sth』s sake; for the sake of; in order that; in order to; so that; so as to; with a view to273 149 get ahead; get ahead of; keep ahead of; one up on; refine on; refine

upon; remain ahead of; stay ahead of277 150 get in contact with; get in touch with; get into touch with; get on to; keep in contact(with); keep in touch(with); make contact with279 151 get out; give away; leak out; let the cat out of the bag; spill the beans; tip off281 152 get through; put through;

walk through; waltz through284 153 give forth; give off; give out; send forth; send out; throw off; throw out285 154 go up; look up; move up; put up; race up; send up; shoot up287 155 hear about; hear of; hear say; hear speak; hear talk; hear tell; know of; learn about; learn of289 156 hold up; rob

of291 157 hunt down; hunt for; hunt up; in search for; in search of; look about; look after; look around; look for; look out for; look round; look up; search after; search for; search out; seek after; seek for; seek out292 158 in a hurry; in haste; be in haste to(do); hurry up; hustle—and—hustle; m

ake haste; with haste296 159 in place of; instead of; stand in for; take the place of; take sb』s place298 160 in time; in good time; on time300 161 interfere in; interfere with; intervene in; meddle in; nose into; pry into301 162 leave alone; let alone; never mind; not to mention; not to speak of; n

ot to say303 163 lend an ear; lend one』s ear(s); listen for; listen in; listen out; listen to305 164 let on; make believe; make out; pass off; put on307 165 light up; load up; under the influence; under the table;under the weather; wipe out308 166 light up; put on; switch on; turn on310 167 look dow

n on; look down upon; look down one』s nose at; sneeze at; sniff at; spit at312 168 match up; match with; team up; tone in314 169 noise about; noise abroad; noise around; put about;rumor abroad; set about; set abroad; spread about; spread abroad; spread around315 170 now that; seeing that317 171 put

off; put out; shut off; shut down; snap off; switch off; turn off; turn out318 172 see sb.off; send sb.off320 173 set forth; leave for; set off; set out; start for; start off; start out320

鈣離子信號傳導於細胞連結動態所扮演的角色

為了解決Interfere with sb的問題,作者Ivan Limanjaya 這樣論述:

BackgroundDuring spermatogenesis, transient permeability of blood-testis barrier achieved through tight junctional dynamics permits spermatocytes to translocate towards the luminal side of seminiferous tubule. Previous studies indicated that L-selectin regulates this tight junctional dynamics throu

gh its downstream effector Rho GTPase and that binding of L-selectin ligand to its receptors in Sertoli cells leads to influx of calcium. The relationship between this calcium influx and Rho GTPase, however, remains to be elucidated.MethodologyUsing fluorescent dye, real-time imaging on ASC-17D cell

s was performed to observe calcium influx following stimulation with an array of ligands for selectins under various conditions. Active small GTPases pull down assay followed by western blot was also performed to further investigate the relationship between calcium influx and activation of Rho GTPas

es.ResultConsistent with results from previous studies, we confirmed the presence of L-type voltage-operated Ca2+ channel-mediated calcium influx following L-selectin stimulation. In accordance with our hypothesis, we also successfully demonstrated increased expression levels of activated Rho and Ra

c1 as the direct consequence of L-selectin-induced calcium influx.ConclusionActivation of L-selectin induces calcium influx through the L-type VOCC which consequently activates Rho and Rac1 in ASC-17D cells.Our findings lead to better understanding of the L-selectin regulated tight junctional dynami

cs. Further continuation of this study might materialise through the investigation of the topological rearrangement of tight junctions following L-selectin-mediated calcium influx.