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Guide to Clinical Hospital Rotations

為了解決Expert的問題，作者Jayakumar, Rebecca A.,Nemecek, Branden D. 這樣論述：

High-yield coverage of common infectious disease states that every pharmacy student needs to knowRotations are essential to the development of skills needed to practice pharmacy, yet there’s very little clear guidance for students seeking to prepare for and make the most of their rotations. Guide

to Clinical Hospital Rotations provides an expert coverage of everything you need to succeed, including signs and symptoms, diagnostic considerations of differential diagnosis, treatment algorithms for empiric therapy and specific step-down therapy, and monitoring of the disease state. The authors

describe the disease, first line of treatment, and DX treatment monitoring. Chapters cover microbiology, antimicrobial regimen selection, urinary tract infections, pneumonia, influenza, respiratory tract infections, sinusitis, skin infections, infectious endocarditis, sepsis and septic shock, HIV, t

uberculosis, and much more.

Expert進入發燒排行的影片

An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決Expert的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

Blade of a Sword: Ernst J�nger and the 73rd Fusilier Regiment on the Western Front, 1914-18

為了解決Expert的問題，作者Strohn, Matthias 這樣論述：

Dr Matthias Strohn was educated at the Universities of Münster (Germany) and Oxford. He has lectured at Oxford University and the Joint Services Command and Staff College at Shrivenham. Since 2006 he has been a lecturer in the Department of War Studies at the Royal Military Academy Sandhurst, and in

2011 he was also made a Senior Research Fellow at the University of Buckingham. He holds a commission in the German army and is currently a member of the military attaché reserve. He lives in Surrey, UK.Dr Strohn has published widely on 20th-century German and European military history and is an ex

pert on the German army in World War I and the inter-war period. He has advised British and German government bodies on the World War I centenary commemorations.

移動平均線搭配馬丁停損利策略之績效研究

為了解決Expert的問題，作者嚴楦鈞 這樣論述：

智能自動交易系統，透過自定義的交易策略代替投資者在市場進行交易，在整個交易操作期間投資者無須介入交易，排除投資者情緒影響的交易操作，更能嚴守交易紀律，驗證單純以技術分析取得的績效成果。本研究針對使用技術指標-移動平均線為進場訊號，配合止盈與止損輔助做為出場方針，將其績效做為基本對照組，再與添加馬丁格爾做為進場資金的策略進行對比績效之差異。經研究結果發現添加馬丁格爾策略做為進場資金的投入後，有利提升獲利之穩定性，並降低面臨的虧損風險。