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Birthing Liberation: How Reproductive Justice Can Set Us Free

為了解決C:set的問題，作者Wade, Sabia 這樣論述：

Black maternal mortality statistics have not shifted in the past thirty years. The maternal mortality rate for Black patients is four to five times higher than it is for White patients. This is just one example of racism as a health and national crisis, but it is a particularly tragic one. Birthi

ng Liberation presents reproductive justice as the pathway to equity. The issue of reproductive justice may sound specific, but it is in fact the birthplace of liberation. Its four guiding principles--analyzing power systems, addressing intersecting oppressions, centering the most marginalized, and

joining together across issues and identities--have the power to lead us to collective liberation in all facets of life. Collective liberation rests on the idea that in order for us all to have equity in this world--from the safety of birthing children, to the ability to bring a baby home to a safe

community, to having access to resources, safety, and opportunities over the long term--we must all become liberated individuals. Sabia C. Wade is a renowned radical doula and educator inspired to create a guide for how we can all achieve liberation through trauma healing and reproductive justice.

Birthing Liberation creates a path to social and systemic change, starting within the birthing world and expanding far beyond.

Jacques Maritain and Human Rights: Totalitarianism, Anti-Semitism and Democracy (1936-1951)

為了解決C:set的問題，作者Lorenzini, Daniele 這樣論述：

The influence of Jacques Maritain in the post-war era's embrace of human rights is undeniable. Scholars, however, overlook a major shift in his use of language. Daniele Lorenzini argues the turn from Maritain's use of the expression "rights of the person" to "the rights of man" is packed with meanin

g. Reconstructing the historical context in which this shift occurred is key to fully grasping what Maritain accomplished. It is also essential if one seeks to defend Maritain against accusation that he enacted a victory of the American and French modern revolutionary spirit over ecclesiastical teac

hing when he legitimized "the rights of man." The notion that Maritain may have taken up the cause of the civic-secular citizen when these secularly articulated rights were consciously never embraced by Catholic magisterium (that instead promulgated the rights of the person) merits serious attention

. Lorenzini reconstructs Maritain's historical context and theoretical trajectory shaped by particular circumstances--most evidently World War II, but also his time in the United States and his work with the Committee of Catholics for Human Rights. Lorenzini is not suggesting that Maritain staged a

siege of Catholic thought, but that he did in fact lay the foundations for turning the conversation away from the tenets upheld by ecclesiastical authority on the concept of rights toward an articulation that more pointedly connects such rights to the actual possession and protection. How and why t

his happens, Lorenzini demonstrates, is "grasped only if critically situated in the union of history of history and biography that makes this possible and encourages it, as does Maritain's residency in the United States--an exile that obliged the French philosopher to render a deep seated account of

the unbelievable (and tragic) political and intellectual panorama." In short, Maritain set in motion the innovative redefinition of the elements that would soon be known as the human rights. But to Maritain these elements were always proper to the new ideal of the "vitally Christian" political city

, the city "founded essentially on the two 'pillars' of democracy and the safeguarding of the rights of man." What originally began as a purely linguistic investigation of Maritain's use of terminology has led Lorenzini to ask whether Maritain himself was won over from the act of conversing of right

s associated with personhood to the real-time struggle for these rights, an evolution not just of Maritain's language but of the man himself. Lorenzini's work is a formidable contribution to the literature pertaining to the period of post-war thought and Maritain on human rights. In his labors to c

arefully digest the full span of Maritain's intellectual trajectory on rights, Lorenzini brings Jacques Maritain alive both as a man of vision but also fervent action, and defends him from critics and historians that accuse him of spurning Church teaching and papal authority. As Lorenzini's study sh

ows, the human rights of the secular-civic world--whose lineage scholars attribute in large part to Maritain--were always derived from Catholic teaching and intended for use in constructing the truly Christian city. This work stands out in a vast repertoire of work on the subject of Jacques Maritai

n, and accomplishes both high level philosophical and historical sleuthing. It is of particular interest to American readers who may not fully realize the depth of Maritain's maturation of thought during his residency in the United States. This is an astounding read for historians, scholars of polit

ical philosophy, and students of Jacques Maritain. Daniele Lorenzini is Assistant Professor of Philosophy at the University of Warwick, where he is also Deputy Director of the Centre for Research in Post-Kantian European Philosophy. He is the author of Éthique et politique de soi (Vrin, 2015) and

La force du vrai (Le bord de l’eau, 2017), as well as the editor of Foucault and the Making of Subjects (Rowman & Littlefield, 2016).

An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決C:set的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.