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辣木籽油細胞毒性與人類子宮內膜異位基質細胞雌激素生成作用及抗發炎與促進傷口癒合功效評估

為了解決what does sds stand 的問題，作者林峻暐 這樣論述：

辣木(Moringa oleifera)的葉子、種籽、樹皮、根、汁液和花已被廣泛應用於傳統醫學治療並對皮膚有助益。過去有研究針對辣木的葉子萃取物進行其潛在的細胞毒性作用。目前，已知辣木籽油(Moringa oleifera seed oil)具有抗發炎和抗氧化活性外，但其對於血液細胞與皮膚細胞毒性和雌激素作用能力研究卻很少見。因此，本研究目的主要探討辣木籽油對人類血球細胞(HL-60)與人類皮膚角質細胞(HaCaT)的細胞毒性與對臨床手術取下培養之人類子宮內膜異位症基質初代細胞(ESCs)的細胞毒增生作用分析與促雌激素生成作用(Estrogenic effect)。本研究使用的辣木籽油(MO

SO)含有高量油酸(65-85%)，在HL-60毒性分析上觀察到MOSO的安全使用濃度須小於31.25 mg/mL (

Mutation of the Carboxy-Terminal Processing Protease Gene in Acinetobacter baumannii and its Impact on Membrane Integrity and Virulence Properties

為了解決what does sds stand 的問題，作者RakeshRoy 這樣論述：

Acinetobacter baumannii is a gram-negative, opportunistic, multi-drug resistant human pathogen capable of causing various nosocomial infections related to meningitis, urinary tract, bloodstream, gastrointestinal tract and pneumonia. Currently A. baumannii has become resistant to almost all presentl

y available antibiotics and therefore there is an urgent need for the development of novel antimicrobial therapeutic strategies. Of the several potential therapeutic targets, motility is one and studies show that the link between motility and virulence in A. baumannii is less explored. The objective

of this study was to identify motility associated genes in A. baumannii, to characterize gene function and to check for its association with pathogenesis. We generated mini-Tn10 transposon insertion library of 1500 transconjugants, of which twelve showed reduced motility. Analysis of inverse PCR pr

oduct of a mutant, namely MR14 revealed that mini-Tn10 was integrated into ctp. The subcellular localization study showed that Ctp in A. baumannii is localized in the cytoplasmic membrane. Compared to ATCC 17978, MR14 was observed to undergo autolysis and showed loss of membrane integrity. Mutation

of ctp gene led to significantly increased hydrophobicity and biofilm-forming ability. Quantification of biofilm matrix components, biofilm inhibition and disruption assay further revealed eDNA and proteins to be an important component of MR14 biofilm. MR14 exhibited reduced adhesion to and invasion

of A549 cells and displayed increased sensitivity to membrane permeabilizing agents. MR14 displayed hypervesiculation with OMVs of larger mean size and higher cytotoxicity. However, the injection of MR14 into zebrafish showed an increased survival rate by 40% compared to ATCC 17978. Our results str

ongly show that ctp in A. baumannii is important for maintaining membrane integrity and controlling autolysis. Lysis of MR14 results in increased concentration of eDNA and proteins that consequently contribute to increased biofilm forming phenotype. The hypervesiculation phenotype of MR14 is inferre

d to be the consequences of combined action of indirect effect of elevated cell envelope stress response and enhanced membrane defect due to loss of Ctp. Our overall results indicate that ctp in A. baumannii has a pivotal role in positively controlling virulence as shown by invasion and adhesion ass

ay and zebrafish infection model, however, it also negatively controls pathogenic traits via autolysis and OMV biogenesis.